ContraVir Pharmaceuticals to Present CRV431 Phase 1 Data at the International Liver Congress™

EDISON, N.J., April 11, 2019 (GLOBE NEWSWIRE) — ContraVir Pharmaceuticals, Inc. (NASDAQ:CTRV), a biopharmaceutical company focused on the development of therapeutic drugs for the treatment of liver disease arising from non-alcoholic steatohepatitis (NASH) and chronic viral infection, today announced that it will present a poster on a Phase 1 single ascending dose study of CRV431 at the 53rd Annual International Liver Congress™ 2019 (EASL), taking place in Vienna, Austria from April 10-14, 2019.

Dr. Daren Ure, Director of Research and Development, ContraVir Pharmaceuticals, Inc.  will present a study where subjects were treated with escalating doses of CRV431 administered as a single dose to assess safety, tolerability and pharmacokinetic profiles.

Robert Foster, PharmD, PhD, Chief Executive Officer of ContraVir Pharmaceuticals, said, “We are pleased to be invited to present this poster at EASL 2019 as it forms the basis of our continued development of CRV431, a promising therapeutic candidate for hepatitis B and liver disease.”

Presentation Details

A Phase 1 Single Ascending Dose Study of CRV431
Poster presentation number: FRI-171
Authors: Danielle Armas1, Michael Snyder2, Daniel Trepanier2, Daren Ure2, Jill Greytok2, Robert Foster2 
1Celerion, Tempe, AZ, USA; 2Contravir Pharmaceuticals, Inc., Edison, NJ, USA and Edmonton, AB, Canada  
Date: Friday April 12, 2019

About CRV431

CRV431 is a clinical stage cycliphilin inhibitor. Its primary biochemical action is inhibition of cyclophilin isomerase activity, which is known to play a key role in protein folding. In non-clinical, experimental models of NASH, CRV431 reduced fibrosis scores and hepatocellular carcinoma (HCC) tumor burden. In addition, CRV431 has also shown activity against certain viruses including HBV, HCV, and HIV-1. CRV431 has demonstrated an ability to reduce multiple markers of HBV infection including reductions in DNA, HBsAg, HBeAg, and HBV uptake by liver cells. These multiple modes of action may play an important role in the overall treatment of liver disease, from triggering events through to end-stage liver disease. CRV431 has completed phase 1 human clinical trials.

About ContraVir Pharmaceuticals

ContraVir is a biopharmaceutical company focused on the development of targeted therapies for liver disease arising from non-alcoholic steatohepatitis (NASH) and chronic hepatitis B, C and D viruses (HBV, HVC, HDV). The company’s lead drug candidate is CRV431, a novel cyclophilin inhibitor.  In vitro and in vivo studies have thus far demonstrated that CRV431 reduces liver fibrosis and hepatocellular carcinoma tumor burden. CRV431 is also a host-targeting antiviral that reduces important viral proteins, such as those involved in host cell entry and viral replication. For more information, please visit

Forward Looking Statements

Certain statements in this press release are forward-looking within the meaning of the Private Securities Litigation Reform Act of 1995.  These statements may be identified by the use of forward-looking words such as “anticipate,” “believe,” “forecast,” “estimated,” and “intend,” among others. These forward-looking statements are based on ContraVir’s current expectations and actual results could differ materially.  There are a number of factors that could cause actual events to differ materially from those indicated by such forward-looking statements. These factors include, but are not limited to, substantial competition; our ability to continue as a going concern; our need for additional financing; uncertainties of patent protection and litigation; uncertainties with respect to lengthy and expensive clinical trials, that results of earlier studies and trials may not be predictive of future trial results; uncertainties of government or third party payer reimbursement; limited sales and marketing efforts and dependence upon third parties; and risks related to failure to obtain FDA clearances or approvals and noncompliance with FDA regulations. As with any drug candidates under development, there are significant risks in the development, regulatory approval, and commercialization of new products.  There are no guarantees that future clinical trials discussed in this press release will be completed or successful, or that any product will receive regulatory approval for any indication or prove to be commercially successful.  ContraVir does not undertake an obligation to update or revise any forward-looking statement. Investors should read the risk factors set forth in ContraVir’s Form 10-K for the year ended December 30, 2017 and other periodic reports filed with the Securities and Exchange Commission.

For further information, please contact:

Stephen Kilmer
ContraVir Investor Relations
(646) 274-3580 

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